How pervasive was pregnancy drug use in the 1960s? We can look at two cohorts, the CHDS (Child Health and Development Study) and the Collaborative Perinatal Project to get a sense of this vast history. The top chart shows CHDS drug use throughout pregnancy, and the bottom two refer to drug CHDS and CPP drug use in roughly the first half of pregnancy.
Use of anti-nausea drugs, sedatives, hormones, painkillers and amphetamines were all common. Which of these abnormal exposures entered the womb and fetal tissue? All of them. Which of these affected fetal development? Most of them, though sometimes very subtly. Which of them affected fetal germline? Well, we hope to find out.