The Mother of All FDA Fails

The FDA has never required drug safety assessment for fetal germline impact, even though FDA staff understand that gestational exposures can adversely affect developing germ cells. We must end this catastrophic omission, while also granting all Americans access to their own prenatal medical records.

What causes autism?

Though we believe the germline exposure syndrome is likely a significant contributor to skyrocketing autism rates, the markedly abnormal neurodevelopment we call autism has many other known and suspected triggers, including:

• Prenatal (proximal, first-generation) drug exposures, including antidepressants, anticonvulsants, and terbutaline
• Epigenetic consequences (including imprinting disorders) stemming from fertility treatments such as IVF and ICSI
• Prematurity, multiple births and perinatal complications (sometimes also relating to assisted fertility)
• Prenatal infections, autoimmunity and inflammation
• Classic random de novo genetic mutations
• Familial genetic syndromes such as Fragile X
• Fetal hypothyroidism
• Post-natal events such as encephalitis and acute inflammation

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