The Mother of All FDA Fails

The FDA has never required drug safety assessment for fetal germline impact, even though FDA staff understand that gestational exposures can adversely affect developing germ cells. We must end this catastrophic omission, while also granting all Americans access to their own prenatal medical records.

Worse than thalidomide? The consequences of mass prenatal progestin exposure, 1950s-70s


by Jill Escher (Follow me on Twitter @autism_exposed)

When we think of prenatal drug disasters, we usually think of the sedative thalidomide, which caused horrific birth defects, and synthetic estrogen DES, which caused cancer and infertility in offspring, among other horrors.

Ignored, however, have been the downstream effects of the extensive use of progestin drugs in obstetric and fertility practice from the late 1950s through today. Progestins, not estrogens, were the most widely used anti-miscarriage drugs during several decades of practice that placed near-unquestioning faith in modern pharmaceuticals combined with near-nonexistent concern about impacts on the fetus.

These potent pseudo-hormones were given to countless millions of women who were deemed to be “at-risk” for miscarriage or who were termed “habitual aborters,” defined very liberally at the time as women who had suffered two or three prior miscarriages. The most common synthetic progestins administered in these protocols appear to have been Colprosterone, Delalutin, Deluteval, Norlutin Acetate, Provera, and Provest. (Reinisch and Karow, Prenatal Exposure to Synthetic Progestins and Estrogens: Effects on Human Development, Arch. Sex. Behav. 6:4 1977).

A 1969 medical text, “The Use of Progestins in Obstetrics and Gynecology,” by RW Kistner explained to physicians the then-standard of care for treatment of the “habitual aborters.” Please note the acute nature of the timing and dosage; the old practices resulted in massive fetal exposure to high doses of potent endocrine disrupting chemicals.
Provera: ... 10 mg daily, orally, during the first trimester of pregnancy; then 20 mg daily, orally, during the second trimester and 30 mg, daily, orally, during the third trimester.

Delalutin: (hydroxyprogesterone caproate) 375-500 mg (3-4 cc., intramuscularly) every week, starting as soon as pregnancy is confirmed and continuing to fetal viability.

Deluteval (hydroxyprogesterone caproate plus estradiol valerate): 500 mg. Delalutin plus 10 mg Delestrogen, intramuscularly, every week from the time of confirmation of pregnancy until fetal viability.”

If progesterone is administered, it is best started before conception and continued during pregnancy.... Progesterone, hydroxyprogesterone caproate and oral medroxyprogesterone acetate may be used in the prophylatic management of the habitual aborter.
Kistner, pp 112-13.

Nine years earlier, Dr. Edward Tyler, founder of the Tyler Medical Clinic in Los Angeles, had published his influential 1960 book, “Sterility: Office Management of the Infertile Couple,” (available online free at http://catalog.hathitrust.org/Record/001566807) which touted the use of the new synthetic hormones for a variety of fertility and other obstetric problems.

Dr. Tyler also endorsed large doses of synthetic progestins for miscarriage prevention:
A new injectable progestogen, 17a-hydroxyprogesterone caproate (17-AHPC) [note: this is Delalutin, which had been approved by the FDA for miscarriage prevention in 1956], differs from progestone in two major respects: large doses, for example, 250 mg per injection, can be given with relative freedom from local reactions; and, the therapeutic effect of each injection is prolonged so that a single injection produces progestational activity for 8 to 10 days. These qualities of prolonged action and relative freedom from local reactions make 17-AHPC a generally more desirable therapeutic agent than progesterone for intramuscular use, but dosage must be controlled carefully.
Sterility, pp. 253-56. Tyler's colleague, Dr. M Edward Davis, contributed a chapter concerning endocrine therapy for threatened miscarriage, explaining the theoretical basis for such intervention.
Progesterone is the pregnancy hormone and the logical substance to use in threatened abortion. If it can be demonstrated that the pregnancy is still viable, this hormone can be administered in moderately large doses. This key steroid may compensate for inadequate production of hormones by the corpus luteum or early chorion. Temporary supplementation of this vital steroid may bridge the gap during the transition from corpus luteum to chorionic hormonal support of the pregnancy. 
It has been argued by some authors that no therapy is indicated in patients who threaten to abort, for in more than one-half of these women threatening symptoms will subside and the pregnancies will culminate successfully. Furthermore, the high incidence of ovular defects decreases tremendously the number of pregnancies that are worth salvaging. However, such an attitude of defeat and resignation does not conform with modern dynamic medicine. If only 5 or 10 per cent of patients in whom the threatened abortion would have become inevitable can be helped to carry their pregnancies by intelligent therapy it is worthwhile.
Sterility, pp. 326-27 (emphasis mine). Dr. Davis continues his enthusiastic endorsement of the "over-abundant" clinical use of synthetic progesterones in “modern dynamic medicine” as follows:
Until the last two years, 100 mg of progesterone in oil was administered intramuscularly to the patient four or five times each week. This was continued until she felt life at about 16 to 18 weeks if on previous occasions she belonged to the group who aborted early in pregnancy. If the pattern for previous abortions indicated that the terminations occurred most often at midpregnancy, however, the medication was continued until the baby reached a safe period of viability, about 6 weeks from term. No other steroids were administered.
The frequency of the intramuscular administration and the occasional discomfort they induced interfered to some extent in the above regimen. Unfortunately, progesterone is metabolized rapidly, for the administration of 50 mg per day to the patient who is not pregnant produces no holdover effects for longer than 48 hours. The introduction of 17a-hydroxyprogesterone caproate (Delalutin) provided a long-acting progestational agent. Although its metabolism differs from crystalline progesterone, its biologic action is similar. The length of its action is dependent on an adequate supply of estrogens. It is possible that additional estrogens may be indicated in some cases. The habitual aborter can now receive 250 mg of 17a-hydroxyprogesterone caproate intramuscularly twice a week, or even 500 mg once a week. There have been no undesirable sequelae following the administration of this new progestational agent. The administration of crystalline progesterone and 17a-hydroxyprogesterone caproate during pregnancy has not resulted in virilism in the newborns in our experience.
[...]
[A]n overabundance of [progesterone] may improve the uterine environment of the conceptus and result in a more adequate circulation, a more substantial implantation, and a quiescent abode for the embryo.
Sterility, pp. 332-333.

It is very important to note that in a subset of infertility patients, the use of corticosteroids such as prednisolone was also advised. These cases included women with adrenogenital syndrome, women with amenorrhea, or infrequent menses, and with no signs of masculinization, patients with fallopian tube obstruction, patients with long- standing infertility, and a group of husbands showing oligospermia. Sterility pp. 381-82. Tyler described the clinical use of prednisolone for fertility as follows:
Patients were given 5 mg four times daily for 2 days, then 5 mg three times daily for 2 days, and then were placed on a maintenance dosage of 5 mg twice daily for 12 weeks, or slightly longer. When therapy was to be discontinued the dosage was tapered off gradually, so that during one week 5 mg was administered daily, and the dose decreased to 5 mg every other day the following 2 weeks, then 5 mg twice a week for 2 weeks, at which time the medication was then stopped.
Sterility, p. 382.

In sum, the literature reflects a once widespread medical practice of prophylactically drugging pregnant women who had suffered more than one previous miscarriage with heavy doses of synthetic hormones, particularly progestins, and to a lesser extent estrogens and corticosteroids, sometimes in combination with each other. This practice was particularly prevalent among somewhat upper income women who could afford the expensive therapies.

I am a perfect example of a child exposed in utero to these synthetic chemicals in the 1960s.  As fate would have it, I was the subject of the study, "Prenatal Exposure to Synthetic Progestins and Estrogens: Effects on Human Development," by Dr. June Reinish.  Thanks to meticulous record-keeping by Dr. Reinisch and the Kinsey Institute, where she had served as director,  I just recently obtained the records of my own exposures.  They were:





Deladroxate (dihydroxyprogesterone acetophenide enanthate, maybe combined with 10-mg estradiol) by injection for 7 weeks, 100 mg once a week (first trimester);

Deluteval (hydroxyprogesterone caproate (also known as Delalutin) plus estradiol valerate) by injection 250 mg every week, for 19 weeks (second and third trimesters); and

Prednisolone, oral, preconception through first trimester, approx. 35 mg for 10 weeks.

A birth control pill has about .2 mg of synthetic hormones. I was exposed to about 6,000 mg [note: at first I thought it was about half that] of these chemicals in utero, most during the first half of pregnancy, the very period during which my eggs developed. As far as I can tell, although millions of us were exposed to these insane and genotoxic anti-miscarriage protocols, I'm the only one who has recovered her prenatal records.

The heavy use of synthetic hormones for anti-miscarriage began to fade in the 1970s, first with the revelations about DES toxicity in 1971, and then with the publication of various studies beginning to question the fetal impacts of these exposures, including, notably, the aforementioned 1977 study of developmental effects by June Reinisch, in which she found distinct personality differences in the exposed children, as compared to their unexposed siblings. The differences can be summed up this way: we were a bit “Aspie,” that is more independent and less groupish, and somewhat gender-bended. Reinisch and others later found prenatal corticosteroid exposure to have teratogenic effects on the fetus, including fetal growth retardation.

OH DEAR, you are thinking, WHY DOES ANY OF THIS MATTER?  I TURNED OUT OKAY, RIGHT?

Yes, I turned out okay, but my children are not.  They are autistic.  Their brains do not work.  They cannot talk.  They cannot learn.  They spend their days engaged in constant stims, like shredding paper or chewing on toys.  They will never have jobs.  They will require tens of millions of dollars in 24/7 support over their lifetimes.  And now, seemingly out of the blue, there are hundreds of thousands of others just like them.

You see, the drugs screwed up my eggs.  The process of fetal germline (egg or sperm) development depends on the appropriate delivery of precise chemical messages, including hormonal molecules. Impostor hormones such as progestins, estrogens or corticosteroids, singularly and in combination, can hijack a fragile and unfathomably complex system that evolved over billions of years, upsetting the normal molecularly-controlled developmental processes necessary for normal sperm and egg development. This process has been demonstrated in a great many studies over the past decade. [FN1]  In addition, as mentioned above, the use of these novel synthetic medications was particularly intense in the first half of pregnancy, which is precisely the timeframe of epigenetic programming of the vulnerable fetal germline.

Did progestins, with or without combined estrogens and corticosteroids scramble the intracellular signals needed for normal epigenetic synthesis, resulting in developmental abnormalities in our egg and sperm, and therefore in our progeny, our children? In light of the vast exposure history, what we know about germline disruption caused by impostor hormones, and the strongly epigenetic nature of neurodevelopment, it is more than plausible, it is indeed highly likely. Already I have found many autism families with prenatal exposure histories just like mine.

It is time for the “hidden history” of mass use of progestins and other endocrine-disrupting synthetic steroid hormone drugs in pregnancy to come out of the closet. Researchers are almost totally ignorant about what occurred in countless doctor's offices over several decades, resulting in one of the greatest toxic events in the history of humanity. No doubt, it will explain a portion of the glut of quasi-genetic disorders in the generation born 1980s to today, a generation rife with autism, ADHD, mental disorders, learning disabilities, and other “idiopathic” public health mysteries of our era. If there is a connection, and of course there is, the implications are vast and of profound importance.


FN1 Endocrine disrupting compounds have repeatedly been shown to induce epimutations and impact gene expression profiles of germ cells, at both low and high doses. See, eg, Manikkam et al, Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations, PLOS One 8(1): e55387. doi:10.1371/journal.pone. 0055387 (2013); Crews, Epigenetic transgenerational inheritance of altered stress responses, PNAS USA. 2012 doi: 10.1073/pnas.1118514109; Susiarjo et al 2013, Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse, PLoS Genet 9(4): e1003401. doi:10.1371/journal.pgen.1003401; Walker and Gore, Transgenerational neuroendocrine disruption of reproduction, Nature Reviews Endocrinology 7, 197-207 2011. Doyle et al. (2013), Transgenerational Effects of Phthalate on Male Germ Cells, BOR Papers in Press Published on March 27, 2013 as DOI:10.1095/biolreprod.112.106104; Manikkam et al, Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations, PLoS ONE 7(9): e46249. doi:10.1371/journal.pone.0046249 (2012); Del Mazo et al, The effects of different endocrine disruptors defining compound specific alterations of gene expression profiles in the developing testis, Reproductive Toxicology 33:1, 106–115 (2012).

49 comments:

  1. Interesting - especially the fact that you and the others in your hormone-exposed group actually feel somewhat gender-bended. This is something I've been trying to make people aware of, that there are significant differences between the brains of men and women that have profound effects on a person's psychology and behaviour later in life. Sexual development is hormone-driven, and exposure to these artificial sex hormones during the second and/or third trimester of pregnancy (which is when most sexually dimorphic brain development takes place), can create a person with an intersexed or partially opposite-sexed brain.
    I think that the increasing use of these drugs during pregnacy is the real reason why we're suddenly seeing so many gender variant people all over the place (and going on what I've seen among the DES sons, probably has a lot to do with soaring rates of infertility and endocrine disorders as well).
    http://desinfo411.wordpress.com/2013/03/07/a-des-son-speaks-out/

    ReplyDelete
    Replies
    1. My name is Alan. I was born on 08-15-50. I have struggled all my life due to the fact that my mother took thalidomide during the 2nd or 3rd trimester of pregnancy for nausea. I have been searching for some time now for information on why I want to be with men, yet am so very sickened to have sex with them. Most of my friends are women because I don't feel like much of a man. My mother did not tell me about the thalidomide until I was 51 yrs. old. She has been so harsh and belittling and led me to believe I was just a mutant. I really wish there were a way to wrap my head around all this so I could feel better about myself, defects and all. martad15.wm@gmail.com

      Delete
    2. Thankes to Dr OSAZE, who cured me of fallopian tube blockage and fibroid. i married for over eight years wthout a child of my own. because of the problem with my fallopian tubbe and fibroid, until i came in conntact with Dr OSAZE's testimony and recommendations online, on how he has cured and healed so many people of the same illment, and i decided to contact him, and he administered his medicatons on me, and i became pregnant in two monnths. incasse you wannt to reach him for a similar problem, you can call or whatsap him on +2347089275769 or email: DROSAZEHERBAL@GMAIL.COM

      Delete
  2. Thanks, Hugh, for your comment. I totally agree with you. There's no question my exposure to multiple synthetic hormones in utero had a variety of impacts on my body, brain, and germ cells (eggs). In terms of sexual identity, I'm very heterosexual but have always fought against a tomboy edge, wishing I could somehow pull off pink and frilly (I can't). Physically, I'm all girl but with some slightly strange proportions and asymmetries (thanks, prednisolone).

    To learn more about effects of synthetic hormone exposure (and more), please watch this recent presentation by June Reinisch, PhD, director emerita of the Kinsey Institute and an authority on developmental effects of these exposures:

    http://media.mindinstitute.org/video/epigenetics/reinisch_epigenetics_2013_web.mov

    jill e

    ReplyDelete
  3. That presentation was quite interesting. I do recall reading somewhere that epigenetic programming of DNA differs between eggs and sperm, so it seems plausible that progestins and other artificial sex hormones could interfere with epigenetic programming as part of messing up the normal process of sexually dimorphic development.

    The early progestins are actually derivatives of the testosterone molecule, and have the ability to push female development into the male pathway. See:
    http://en.wikipedia.org/wiki/Progestin-induced_virilisation
    If you're right about the number of women given progestins in the course of miscarriage treatment during the 1950s and 60s, the true number of baby girls born intersexed due to progestin exposure must be far larger than the 160 or so cases mentioned in the article. As with intersex conditions in baby boys due to DES, that disaster has been completely hidden from the public (but at least it has a Wikipedia article!).

    Ovulation is quite a complex process involving a kind of hormonal feedback loop between the hypothalamus and pituitary in the brain, and the maturing egg in the ovaries that is being prepared for release that month. There's a critical window during brain development where exposure to masculinising hormones will masculinise the hypothalamus and pituitary so they are no longer capable of generating the appropriate signals for ovulation (the "LH surge") later in life. At least that's what happens in sheep, and presumably the same is true in humans too.

    "The results of the present study clearly document that exposure of the female sheep fetus to androgens during a critical period for sexual differentiation of the brain progressively disrupts reproductive cycles in the adult ewe. Similar effects of androgenization on reproductive function have been described in other species. Specifically, the effects of prenatal androgen exposure have been shown to alter the timing of puberty in female rats (20), guinea pigs (21), and primates (22). In addition, pre- or neonatal testosterone treatment leads to the production of abnormal reproductive cycles in rodents (23) and primates (24), supporting the conjecture that a relatively short exposure to male gonadal hormones early in development can program the reproductive axis of the female to malfunction in later life, leading to sub- or infertility."
    (taken from the discussion section of "Prenatal programming of reproductive neuroendocrine function", http://www.ncbi.nlm.nih.gov/pubmed/12639926)

    The sheep in that experiment were no longer able to generate the LH surge that normally triggers egg release, but while they were young, their system was able to compensate enough so that most were still able to produce eggs and become pregnant. None of them became pregnant during the second breeding cycle though. Basically they suffered from reduced fertility and premature reproductive failure.

    I'm wondering whether the human equivalent of those sheep are women with polycystic ovary syndrome, i.e. that PCOS is actually an iatrogenic condition caused by being prenatally exposed to progestins. Women with PCOS aren't able to generate a normal LH surge and one effect of that is that they have eggs that failed to release properly turning into ovarian cysts. Other effects are that probably the eggs that do get released often aren't in the correct stage of development, which might be contributing to autism and other 3rd generation effects. Does that theory sound plausible?

    ReplyDelete
  4. Jill, I think that feeling's mutual - in a platonic way of course!

    It seems like we've stumbled on two different aspects of the same, larger problem: developmental abnormalities caused by medical hormone use in pregnancy. I've been focusing on the potential these drugs have to cause intersexed or opposite-sexed brain development and produce a person whose brain doesn't properly match their physical sex. You've been looking at them as a cause of disrupted epigenetic programming in germ cells, leading to autism in the F2 generation.

    I think these are just two aspects of a bigger problem though, which is that steroid hormones seem to be heavily involved in controlling many aspects of the growth and development taking place in an unborn child. When you add artificial medical hormones to the mix they completely scramble this chemical messaging system. The result is that whatever part of the body or brain that happens to be developing at the time ends up being built incorrectly, and this leads to all sorts of often subtle developmental abnormalities that don't necessarily manifest themselves until much later in life.

    Steroid hormones and steroid hormone mimics are probably the single most widely used class of drugs there are, and yet they appear to have this terrible dark side to them which nobody wants to acknowledge or admit to because so many people are potentially affected. It's like the situation you sometimes get in business, where a disastrously ill-conceived project keeps lumbering on and on for years because so much money has already been sunk on it that nobody is prepared to be the one to admit the mistake and pull the plug. Well, that's how I see it anyway! What do you think?

    P.S. feel free to contact me by email if you wish.

    Hugh

    ReplyDelete
  5. This comment has been removed by the author.

    ReplyDelete
  6. Hi Hugh,
    You are seriously brilliant and absolutely correct on all counts. People have no clue how totally important this issue is, how catastrophic the consequences have been. Where is Rachel Carson when we need her? How can we be so blind to this folly?
    I would love to email you, could you send me your address to autismhormoneproject@gmail.com? Important things are about to HAPPEN. SERIOUSLY.
    Still in love with you (in whatever way! :) )
    jill e

    ReplyDelete
  7. Dear Jill,
    Thank you for your most informative blog. I really appreciate your efforts to articulate this phenomenon. I too was exposed to a form of progesterone in utero. This was given to my mother in an attempt to avoid repeated miscarriage. I know this because I questioned the doctor who prescribed her medication. Unlike yourself, I have experienced multiple effects of the type now recognised as connected to endocrine disrupting chemicals, affecting the reproductive, neurological and immune systems. Prominent among these are: unilateral failure of breast development; depression; multiple allergies, food drug and chemical intolerances; a condition resembling hemiplegic migraine and various chronic inflammatory problems. I had already worked out the connection with chemical exposure, both in utero and environmentally, but it is illuminating to read about your experience with autism. I also appreciate your experience trying to gain recognition for this issue. I too think endocrine disruption is the coming issue with enormous health implications but it is profoundly challenging to our current culture and to the medical, drug and chemical industries, hence the denial. I am now a physician and health scientist and having recently retired, I am planning to establish a website on the subject to help bring people together here in the UK. I would appreciate any relevant information or advice you may have available.
    Best wishes, Cath M

    ReplyDelete
  8. Great to hear from you, Cath, and I'm sorry to hear your story. But I am thrilled you are planning to establish a website on the subject of the enduring deleterious consequences of old prenatal exposures.

    Most resources I know of are linked via this blog, especially the recent post on the Escher Fund for Autism, and also as videos and research links on autismepigenetics.org.

    The mass ignorance of the history of mass prenatal pharmaceutical use is shocking, but so is the mass ignorance about the ongoing, multigenerational effects thereof.

    If you can email me your email address, I can forward you two PDFs of presentations I'm making this month here in California, one at the Environmental Mutagenesis and Genomics Society (a really big deal!), and one at a local autism conference. They are packed with info you are free to use. Please email autismhormoneproject@gmail.com.

    Thank you for finding my blog and your interest in this horrible hidden history.

    ReplyDelete
  9. It is really good to finally make contact with someone else who has experienced this type of chemical damage. My sympathies go out to you too for the awful hurt it has caused you and your family. I agree, it is amazing how such a major issue can be swept under the carpet and remain out of sight. I suppose, not only is it a very difficult subject to study (in humans), or even talk about, but few people care to admit to making big mistakes, particularly on such a grand scale. I see it as a distinct part of the wider problem of exposure to chemicals via drugs, foods, lifestyles and the environment which add up to a kind of toxic 'brave new world'. I would be very interested to see your presentations and I'll e-mail you shortly. Cath M

    ReplyDelete
  10. My wife was prescribed hydroxyprogrsterone 250mg shots weekly and has taken it for the last 3 weeks due to a short cervix condition and after reading this I think we will stop taking the prescribed shots. What affect if any do you think these 3 doses she took will affect the baby. She started at 20 weeks and she is now 22 weeks pregnant.

    ReplyDelete
  11. Hi Alex, Thanks for writing and for your concern for your baby's health. I am in no way in any position to give medical advice to anyone. But in terms of offering people general education about prenatal exposures to steroid hormone medications, I can only offer these observations based on the existing literature:

    --I don't think there's much reason to be concerned that the exposures will affect the outward health of your baby.

    --There may be some concern, however, that prenatal exposure to steroid hormone drugs, generally speaking, can affect the baby's personality and gender behaviors (as happened with me and demonstrated in a published paper in which I was a study subject)

    --Your baby's germ cells (proto-egg or proto-sperm) may be susceptible to subtle, molecular-level (epigenetic), damage caused by exposure to synthetic hormones. While this, as a broad proposition, is consistent with emerging science, there have been no studies to examine the "germline" effects of prenatal drugs.

    --Most importantly, you will want to retain your wife's pregnancy records so that you can share this information with your child when your child is of age. Your child should have the right to know that he/she was fetally exposed to synthetic hormone drugs. These drugs could potentially impact germ cell integrity, and therefore the developmental integrity of your grandchildren.

    Now, speaking from my own experience, my exposures to synthetic progestins occurred primarily during the first half of gestation, when my eggs were rapidly synthesizing. Perhaps these later-pregnancy exposures, such as your wife is experiencing, will have less of an impact owing to the lower molecular vulnerability of the baby's germ cells.

    As I have no medical advice to offer, I encourage you to ask your clincian what molecular effects he/she thinks these heavy doses of synthetic hormones could have on your baby's germline. I bet it's a question that has never occurred to him/her. The entire field of obstetrics and fertility has somehow forgotten that babies are born with their reproductive cells..., or has chosen not to think about it.

    I do hope your baby is born full-term, as prematurity of course brings many risks. I also wonder why your wife has a short cervix, and I cannot help but wonder what she herself may have been exposed to in utero. Many thanks for writing and I wish your growing family all the best.

    ReplyDelete
  12. Thanks for your response, this is our 4th pregnancy, we had a full term then a miscarriage at 11 weeks, then a premature birth at 35 weeks. The premie is almost 2yrs now and is perfectly healthy. They noticed her short cervice in an ultrasound scan and offered the hydroxyprogesterone to her so that she can deliver full term. After the 2nd pregnancy that resulted in a miscarriage she had a Dnc done to remove the fetus. I'm wondering if there was damage done to her cervix during the procedure. ......at this point we do not feel comfortable proceeding with the hydroxyprogesterone but we are concerned that the 3 doses that she took could have potentially effected the fetus. I guess we will leave it in Gods hands. Thanks

    ReplyDelete
  13. Please consult with your medical provider. While I am no fan of exposing a fetus to synthetic hormones I am of course in no position to give medical advice. For the reasons I stated above I find it unlikely you will see a discernible effect on the baby, just make sure to retain all medical records for later use if necesary.

    ReplyDelete
  14. I am interested in finding out some info on fertility drugs (names) that were used in the early 80s, more specifically the side effects of these drugs on the fetus that then was conceived as a result. i have been unable to find out much information online. any resource would be great. thank you.

    ReplyDelete
  15. My mother took Delalutin in 1971 when she was pregnant with me. I feel I am a bit "Aspie". I'm currently a special education teacher for students with a variety of disabilities and I am curious about the side effects of drugs and hormones in women during this era for personal and professional reasons. I enjoyed reading your article and can relate to it in many ways. Please let me know if I can help spread the word in some way to help make others aware. I believe Makena is on the market still. Thank you, Jill, or anyone else who cares to comment. I'm searching for answers!

    ReplyDelete
  16. First of all thanks for share your personal experience. Meditation and Ayurvedic pregnancy medicine are the best always without side effect. Its Good to Know now a days women are feel secure after getting so much support from Govt. and Family.Even in organizations are gave them Seek leave for long days during Pregnant period.

    ReplyDelete
  17. Great blog.......Fertility medication, better known as fertility drugs, are drugs which enhance reproductive fertility. For women, fertility medication is used to stimulate follicle development of the ovary. There are currently very few fertility medication options available for men.Agents that enhance ovarian activity can be classified as either Gonadotropin releasing hormone, Estrogen antagonists or Gonadotropins.acupuncture services philadelphia

    ReplyDelete
  18. Am pela, thanks to Dr Osaze who cured me of fallopian tube blockage and infertility. My marriage was on the verge of collapsing, because I was unable to bear a child for my husband. Until I came across Dr osaze's recommendation on line, and I contacted him. And he administered his herbs on me. I now have a child I can call my own. In case you want to contact him for a similar problem, or all other issues, you can reach him through his email:
    drosaze39@gmail.com or call him on +2347089275769

    ReplyDelete
  19. This is a letter posted to me by my neice, Debra." The man seated second from the left is the doctor who made it possible for me to be born. Dr. Sydney Page treated my mother with an experimental anti-miscarriage drug which allowed her to carry her first baby to full term - me!. In recent years Mum has had me trying to uncover the name of the drug she was given but so far I've had no luck. There's lots of talk on the internet about a drug referred to DES but Mum says the drug she got was in the form of a slow-release pellet implanted under the skin in her upper thigh, and so far I've not found any mention of DES being administered in this fashion. If anyone can give me any pointers on how to access her medical files through the freedom of information act, or offer any suggestions about the drug she may have been given, please let me know.Debra" Can you please help her out with an answer? Regards Dan Ryan

    ReplyDelete
  20. This is a letter posted to me by my neice, Debra." The man seated second from the left is the doctor who made it possible for me to be born. Dr. Sydney Page treated my mother with an experimental anti-miscarriage drug which allowed her to carry her first baby to full term - me!. In recent years Mum has had me trying to uncover the name of the drug she was given but so far I've had no luck. There's lots of talk on the internet about a drug referred to DES but Mum says the drug she got was in the form of a slow-release pellet implanted under the skin in her upper thigh, and so far I've not found any mention of DES being administered in this fashion. If anyone can give me any pointers on how to access her medical files through the freedom of information act, or offer any suggestions about the drug she may have been given, please let me know.Debra" Can you please help her out with an answer? Regards Dan Ryan

    ReplyDelete
  21. ALL THANKS TO DR WILLIAMS FOR GETTING MY WIFE OUT OF FIBROID WITH HIS HERB One of the greatest moments in this world is when you see your own wife put to bed, this awesome moments makes you a man and not just a man a real man. My wife suffered from Fibroid which made her unable to get pregnant and give us a child for almost 18 years with multiple surgeries done and none seemed to help the situation. I almost gave up but due to the love i had for her because i married her a virgin i had to find a way to help her. I told a member of my church who recommended Dr. williams to me, i contacted her and she sent me a medicine and this medicine shrinked it naturally in weeks it was like magic but it's science. I am happy writing this because she delivered yesterday a baby girl. Do not loose hope too soon contact her on drwilliams098765@gmail.com and i am confident she will help you too.

    ReplyDelete
  22. How i got a cure for PCOS (polycystic ovary syndrome).

    I actually promised myself that i will do this because i never in life thought i would be cured of PCOS because my gynecologist told me there was no cure and because of this i could not take in and get pregnant. I had PCOS (polycystic ovary syndrome) for 7 years and this was a big pain to me and my husband due to the downcast we felt for not having a child. I experienced irregular periods or no periods at all sometimes, heavy periods, i gained weight (fat). I seeked a cure from one doctor to the other used androgen, clomiphene, metformin and even traveled to different states to see other doctors to no avail. My husband got to know about Dr. ALeta via a testimony he read on the internet on how a woman got a cure and he contacted her with the contact she left. I got the herbal medication and used it for the speculated 3 months that was all i have a son who is just 8 months old. Do not give up just contact her on (aletedwin@gmail.com) on how to get the herbal medication. Thanks and i wish you get cured soon too.

    ReplyDelete
  23. I want to say a very big thanks to Almighty God for his good deed,i got my tube tied after my first issue,because of the challenges i was really confronted with,i have being desperately to conceive for five years now in which medical and all other means were to avail,till this days when God give his directives to an Africa man called Dr Ologbo an herbalist,through internet baby center. for God says i will direct your part, he had for me with two months pregnancy with myself convintion and doctor confirmation i must shout a big thanks giving shout out for God word is real and Dr Ologbo as well for fulfilling God earthly promises, he is a man to recon with a man with fear of GOD email him or call him for help for any stander out there facing such challenge his via email Ologbotemple@gmail.com OR call +23473887808

    ReplyDelete
  24. I have had four Miscarriages over the years, and I have not been happy, I search for solution every where all to no avail, My condition became very complex to an extent of me having Miscarriage every five month. Until I got the contact of a doctor from the testimony of Others on the internet. I contacted him made him understand all I have passed through over the years, and he gave me his medication which I too for two month, and now am a mother of three month old Baby name John. If you have such problem, contact the doctor through his email at drsteve833@gmail.com
    Am happy now.

    ReplyDelete
  25. Dr.William product is a real cure to Tinnitus, I am 38 years old, I suffered from permanent tinnitus for about 4 years, mostly in my right ear... which means I've got this constant ringing in my ears, which has also made me somewhat deaf. It's like this Whee! noise in my head all the time. My T was more steady, this is due to prolonged exposure to the loud volume of concerts. Looking after your ears is unfortunately something you don't think about until there's a problem. I wish I'd thought about it earlier. There were days when I didn't know whether I would survive, I was so tormented by this symptoms. When I lay down to sleep it bothers me the most, As I lay my head on the pillow, it cancels out all the other ear. The GoodNews is that after using William Herbal medicine, Tinnitus is gone, try it also it going to work for you. There are real cure and do not be discouraged. Hang in there... Better days will come (email him on: drwilliams098765@gmail.com)

    ReplyDelete
  26. ALL THANKS TO DR WILLIAMS FOR THE GREAT DEED HE HAVE DON FOR MY DAUGHTER
    My daughter suffered from a terrible tinnitus for more than 23 years which started after she turned 5 we all thought it will end but got even worse as days went by. We tried all several treatments and therapy prescribed by various doctors we met but to no avail, she lost total concentration and screamed most times. She usually tells me she hears hissing and ringing noises. This were steady noise that disrupted her entire life, even at night she screams even more because the sounds become louder because everywhere is quiet and she slept less because of this.It was during a casual conversation with a friend that i learned about dr Williams herbal medicine I was able to contact him on his email address. and give him all the necessary information that he needed,few day later he sent me the herbal portion and his medicine was able to restore her back to normal and she is very okay now without any side effects whatsoever. If you have Tinnitus, do not hesitate to contact him on drwilliams098765@gmail.com for advice and for his product. I hope this also helps someone out there.

    ReplyDelete
  27. You must be aware of the use of steroids in the infertility treatment. The generally cause the miscarriage and lower the chance of getting pregnant.

    ReplyDelete
  28. To prevent yourself from different issues in pregnancy you must have to consult http://www.lisapregnancymiraclereview.com/ it is pregnancy miracle book review for assistance in this period anything can happen

    ReplyDelete
  29. I first had symptoms when i was 17 and was told that i had PCOS (thin people type PCOS) and was officially diagnosed at 22 ans now i am 35. I have always had regular periods and unless on birth control pills were they irregular at times and I had a hard time getting pregnant because of the absent periods. I was always told by doctors that I would have a hard time conceiving so I would only go on the pill periodically which i did for more than 4 years, not for protection against getting pregnant, but just to get a period (since I was told it's not healthy to have less than 4 or so periods a year). Last time I went on a 3 month birth control pill and then stopped again because the medicine was not curing my pcos nor making me get pregnant. I went in search for a cure and ended up with so many drugs, medicine and even soaps that didn't work. I actually thought at a point that i was cursed that there is no cure for it, i was prepared to live like that till i read a testimony of a patient who suffered from pcos whose case was even worse than mine and how she was cured completely, I was amazed and at thesame time anxious and curious so i had to contact the doctor with the contact details that she left on the note. The doctor gave me so much hope and confidence with her kind words of encouragement to believe in myself and i was lifted because no one has ever given me hope like that before. I ordered the medicine, took it for 8 weeks and to my complete surprise, all the facial hairs, weight gain and all disappeared within 4 weeks and I ended up getting pregnant within a few weeks of completing the treatment! I was in shock. I think the main reasons it happened was that I never gave up and was ready to try alternative treatment so my body was back to normal. Before now i never enjoyed sex because it was very painful but now i do and my husband is the best thing that ever happened to me.. I hope this inspires some of you because I never in a million years would have thought that I would get pregnant and was getting frustrated and now our baby is due next month! You too can reach her on [aletedwin@gmail.com] for more information, advise and also how to place an order for yours.

    ReplyDelete
  30. This homeopathic remedy can harm both mother and child during the period of pregnancy. levitra

    ReplyDelete
  31. Dr Bello herbal cure is 100% Guarantee percent sure to cure your (HEPATITIS B AND ANY OTHER DISEASE) ,He is only person that i can boldly say he can cure any types of Disease.my wife was having HEPATITIS B for more than 5 year when i met Dr Bello online how and how he has cured so many people and how greatly he has helped many individuals online,so i contacted him and explained my wife situation to him and behold my wife was cure with his herbal medicine and now we are living happily, so to anyone issue on herpes challenges i advised that you contact him for help and he will send you the medication and you will be fine and OK : adeyemibello1990@gmail. com he can also cure any disease such as HIV/AIDS HEPATITIS B,DIABETICS,CANCER,HERPES E.T.C HE is the great herbalist man called Dr.Bello i must say a big thanks for curing my wife disease, i owe you in return. Thanks and be blessed sir.his Mobile number: 09035594773 or what’sapp him on 08107996445

    ReplyDelete
  32. I am sherrie i want to thank greatmutaba@gmail.com for helping me cast a pregnancy spell that got me prenant at the age of 45 years old and gave birth to my child and today he will be 1 year old help me thank greatmutaba@gmail.com

    ReplyDelete
  33. I got cured from PCOS and got pregnant after 8 years of marriage using Dr. Ogbes herbs. Contact Dr. Ogbes today on Landofanswer@hotmail.com or write him here on face book Pregnancy Care. i got pregnant after using the herbal for 21 days. or WhatsApp +2347050270227

    ReplyDelete
  34. I got cured from PCOS and got pregnant after 8 years of marriage using Dr. Ogbes herbs. Contact Dr. Ogbes today on Landofanswer@hotmail.com or write him here on face book Pregnancy Care. i got pregnant after using the herbal for 21 days. or WhatsApp +2347050270227

    ReplyDelete
  35. Hello viewers around the Globe, I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors for me, but none could offer me the help i searched for. i saw some few comments on the INTERNET about this specialist called Dr,OLU and decided to contact him on his email: Drolusolutinthome@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr OLU I also learn that Dr OLU also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr OLU now for help on his email (Drolusolutionhome@gmail.com) or add him on whatsapp line +2348140654426




    Hello viewers around the Globe, I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors for me, but none could offer me the help i searched for. i saw some few comments on the INTERNET about this specialist called Dr,OLU and decided to contact him on his email: Drolusolutinthome@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr OLU I also learn that Dr OLU also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr OLU now for help on his email (Drolusolutionhome@gmail.com) or add him on whatsapp line +2348140654426

    ReplyDelete
  36. With the help of a man called Dr.Ogbes I was able to get pregnant. i'm 56years of age, it was really difficult for me to pregnant though my husband loves me but it was really hurting me not having my own child but after many years I came across Dr.Ogbes whose email address is Landofanswer@hotmail.com or you reach him direct on his cell phone number +2347050270227 he told me he is going to send me a Herbs for me to drink, and will fall pregnant a week after drinking the Herbs i'm 7months pregnant now and also I will like to advice everyone looking for help to get pregnant to contact this very man via his email address at Landofanswer@hotmail.com or call him on his cell phone number +2347050270227.

    ReplyDelete
  37. Human conception requires an egg and sperm. Poor ejaculation ,If you're not ovulating, you won't be able to get pregnant. An-ovulation is a common cause of female infertility and it can be triggered by many conditions. PCOS,Over/underweight,primary Ovarian insufficiency,a thyroid dysfunction,.,hyperprolactinemia, irregular cycle, Blockage in the Fallopian Tubes, when the eggs release from the Ovary did not get to the Fallopian tubes you can not get pregnant Therefore use DR. OGBES Herbal Cleanser to clean up all this Infertility pains in Your Body and get pregnant easy..Landofanswer@hotmail.com.. or Whatsapp +2347050270227 However, regular menstrual cycles don't guarantee that ovulation is occurring.

    ReplyDelete
  38. With the help of a man called Dr.Ogbes I was able to get pregnant. i'm 56years of age, it was really difficult for me to pregnant though my husband loves me but it was really hurting me not having my own child but after many years I came across Dr.Ogbes whose email address is Landofanswer@hotmail.com or you reach him direct on his cell phone number +2347050270227 he told me he is going to send me a Herbs for me to drink, and will fall pregnant a week after drinking the Herbs i'm 7months pregnant now and also I will like to advice everyone looking for help to get pregnant to contact this very man via his email address at Landofanswer@hotmail.com or call him on his cell phone number +2347050270227.

    ReplyDelete
  39. Human conception requires an egg and sperm. Poor ejaculation ,If you're not ovulating, you won't be able to get pregnant. Anovulation is a common cause of female infertility and it can be triggered by many conditions. PCOS,Over/underweight,primary Ovarian insufficiency,a thyroid dysfunction,.,hyperprolactinemia, irregular cycle, Blockage in the Fallopian Tubes, when the eggs release from the Ovary did not get to the Fallopian tubes you can not get pregnant Therefore use DR. OGBES Herbal Cleanser to clean up all this Infertility pains in Your Body and get pregnant easy.. Landofanswer@hotmail.com.. or Whatsapp +2347050270227 However, regular menstrual cycles don't guarantee that ovulation is occurring.

    ReplyDelete
  40. With the help of a man called Dr.Ogbes I was able to get pregnant. i'm 56years of age, it was really difficult for me to pregnant though my husband loves me but it was really hurting me not having my own child but after many years I came across Dr.Ogbes whose email address is Landofanswer@hotmail.com or you reach him direct on his cell phone number +2347050270227 he told me he is going to send me a Herbs for me to drink, and will fall pregnant a week after drinking the Herbs i'm 7months pregnant now and also I will like to advice everyone looking for help to get pregnant to contact this very man via his email address at Landofanswer@hotmail.com or call him on his cell phone number +2347050270227.

    ReplyDelete
  41. Now you should choose which breast pump is perfect for you. Breast pumps may also be used to stimulate milk production and boost your supply. Browse this site to know more about breast pump reviews.

    ReplyDelete
  42. I am very happy to pass this to everyone that is sicking from any kind of disease that the solution to all diseases and sickness have arrive, i was just cured by Dr idahosa the great healer after i have been passing through stress all day and night. i never know i was going to be cured of this HIV sickness in my life cause they said there is no cure, i am proving all those that said that there is no cure wrong cause i have just been cured with herbal medicine of Dr idahosa the great healer, i cant talk cause my heart is full of excitement and i am using this medium of my testimony to inform you all to contact this man for any kind of sickness and he is ready to help you solve your problem. please if you are out there passing through any sickness kindly contact him here through his email address:{ dridahosasolutioncenter@gmail.com } whatssap number +2348134261542,  he  is waiting for you. once more i say a very big thank you for what you have done for me, i will keep my promise to keep sharing testimony about what God have use you to do in my life.
    Dr Idahosa also cure listed diseases:

    1, Night sweats
    2, Lesions on your tongue or mouth
    3, Weight loss
    4, Frequent fever
    5, Persistent Diarrhea
    6, Skin rashes
    7, Tiredness
    8, Swollen lymph glands
    9, Pneumonia
    10, Memory loss
    11, Depression
    12, Swelling of the lymph glands
    13, Red, brown, pink spots on the skin, mouth, nose, or eyelids
    14, Sores of the mouth, anus, or genitals
    15' HIV/AIDS
    16' Herpes virus
    17, Penis Enlargement
    18, Hepatitis AB and C
    19, Diabetes
    20, Ulcer

    ReplyDelete
  43. Hello, Complement of the season. My name is MONA SUZAN , am from USA . I am here to let you know about the solution to your health problem, the cure is out there. I was cured of HIV, with the use of a herbal medicine from Dr OSE . I was diagnosed with this virus for almost 12yrs but i was cured within few weeks after drinking the herbs which Dr OSE sent to me through courier delivery services. Dr OSE is a herbalist doctor. He has herbs for the following illness, asthma, cancer, Diabetic 1&2, Gonorrhea, Barrenness, Impotence, High Blood Pressure,Epilepsy, Herpes 1&2, Hiv leukemia etc Or if you are having spiritual battle like nightmares, bad luck, no profit in business or do you need your Ex girlfriend/ boyfriend back? He is also a spell caster. EMAIL ADDRESS____ droseherbalremedy@gmail com Call or what-sap him on .+2349078751746 Please once you are cured, let people know about it. Together, we fight to become healthy. 

    ReplyDelete

  44. my name is Zoe Heffernan from London, Am here to share how lady cafai unblocked my both tubes with the herbal medicine which i ordered IYa Hindi product from the online i got from this group,of which i was told by my doctor after several attempts trying to get pregnant that both my tubes were blocked. right now am with the scan and the test proving that my tubes are unblocked and as i'm giving this testimony am already 8 months pregnant. i just want to say a big thanks to IYa Hindi herbal for the work done, IYa Hindi herbal has really proven to me that her herbal medicine works perfectly whatsapp messenger +19145295224/visits his register website: https://iyahindinative.com/

    ReplyDelete
  45. I want to use this means to let the world know that all hope is not lost Getting pregnant after having tubes clamped and burned, I know IVF and Reversal could help but the cost is way too high, i couldn't afford it either and i so desire to add another baby to my family been trying for 5 years, not until i came across Priest Babaka, who cast a pregnancy/Fertility spell for me and i use his herbal remedy/medication and i got pregnant. l hope that women out there who are going through the same fears and worries l went through in GETTING PREGNANT , will find your contact as i drop it here on this site, and solution will come to them as they contact you. Thank you and God bless you to reach him email via: babaka.wolf@gmail.com or Facebook at priest.babaka

    ReplyDelete